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Revolutionary ‘Living Valve’ Innovation by Sir Magdi Yacoub Promises to Transform Heart Surgery

January 15, 2025
Professor Sir Magdi Yacoub

Renowned heart surgeon Professor Sir Magdi Yacoub has unveiled a groundbreaking advancement in cardiac care: a “living valve” that grows naturally within a patient’s body.  Sir Magdi Yacoub, reflecting on the development of the “living valve,” remarked, “I always say that nature is the greatest technology. It’s so superior to anything we can make. Once something is alive—whether it’s a cell, a tissue, or a valve—it adapts by itself. Biology is like magic.” Traditional heart valve replacements, whether mechanical or biological, come with significant limitations. Mechanical valves necessitate lifelong blood-thinning medication, while biological valves from animal or human donors typically last about 10 to 15 years and may be rejected by the body’s immune system. These challenges are especially pronounced in pediatric patients, as conventional valves do not grow with the child, leading to multiple surgeries over time.  Sir Yacoub’s team has developed a biodegradable valve scaffold composed of microscopic fibers. Once implanted, this scaffold attracts the patient’s own cells, facilitating the formation of a living valve made entirely of native tissue. Over time, the scaffold dissolves, leaving behind a fully functional valve that integrates seamlessly with the body’s natural…


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